Role of tumour-derived exosomes in chemotherapy resistance in ovarian cancer - PhD Scholarship

Summary

Enrolment status New students
Student type Domestic students, International students
Level of study Higher Degree by Research
Study area Health and Behavioural Sciences, Medicine, Science and Mathematics
HDR funding type Living stipend scholarship, Tuition Scholarship
Scholarship value $28,092 per annum tax free (2020 rate) indexed annually
Scholarship duration Three years with the possibility of two 6-month extensions in approved circumstances
Opening date 16 October 2019
Closing date 17 November 2019

Scholarship description

Chemoresistance is one of the major obstacles in the treatment of cancer patients.  It poses a fundamental challenge to the effectiveness of chemotherapy and is often linked to relapse in patients. Chemoresistant cells can be identified in different types of cancers, however, ovarian cancer has one of the highest rates of chemoresistance-related relapse (50% of patients within 5 years). Resistance in cells can either develop through prolonged cycles of treatment or through intrinsic pathways. Mechanistically, the problem of drug resistance is complex mainly because numerous factors are involved, such as overexpression of drug efflux pumps, drug inactivation, DNA repair mechanisms and alterations to and/or mutations in the drug target. Additionally, there is strong evidence that circulating miRNAs participate in the development of chemoresistance. The past decade has observed an extraordinary explosion of research in the field of EVs, especially in a specific type of EVs originating from endosomal compartments, called exosomes. Exosomes are a specific subtype of secreted vesicles that are defined as small (~30-120 nm) but very stable membrane vesicles that are released from a wide range of cells, including healthy and cancer cells. As the content of exosomes is cell type specific, we recently proposed that the exosomes are “fingerprints” of the releasing cells and their metabolic status. Exosomes released from cancer cells may modify the phenotype of target cells inducing cancerous phenotype, contributing to tumour growth and metastasis. Exosomes from ovarian carcinoma cells are present in the peripheral circulation. Condition-specific changes in the concentration of tumour-derived exosomes may be of clinical utility in the early identification of women with ovarian cancer.

Eligibility

To be eligible to apply you must meet the entry requirements for Higher Degrees by Research at UQ, please visit the Graduate School's website.

Applications are closed.

Before you apply

If this scholarship has rules, download and read them before applying.

How to apply

To apply for admission and scholarship, follow the link in the upper right hand side of this page. There is no separate application for scholarship because you will be given the opportunity to request scholarship consideration on the application for admission.

Prior to applying, check your eligibility and prepare your documentation.

You should also contact Dr. Carlos Salomon (c.salomongallo@uq.edu.au) to discuss your suitability for this scholarship prior to submitting an application.

Please ensure that you

  1. select 'I am applying for, or have been awarded a scholarship or sponsorship'
  2. enter in the free-text field 'ovarian’
  3. list the enrolling unit as the Faculty of Medicine
  4. enter Dr. Carlos Salomon as your supervisor

Selection criteria

Applicants will have a Bachelor of Science with first class honours or international equivalent in biology, biomedicine, or related science and would be competitive for a Research Training Program scholarship or equivalent. Applicants will have practical experience in the lab working on a scientific project. Applicants should also have excellent communication and English language skills. Background experience in relevant areas such as proteomics, gene expression analyses and cancer biology would be highly advantageous. Strong academic performance demonstrated through publication output in peer reviewed international journals is highly desirable.

Applications are closed.

Contact

Dr Carlos Salomon
+61 7 3346 5044
Applications are closed.

Terms and conditions

Read the policy on UQ Research Scholarships.

A domestic part-time student with carer’s responsibilities, a medical condition or a disability, which prevents them from studying full time may be eligible for scholarship consideration, on a case by case basis.

Applications are closed.