Understanding the dynamics of the blood-brain barrier in response to therapeutic ultrasound - PhD scholarship

Summary

Enrolment status New students
Student type Domestic students, International students
Level of study Higher Degree by Research
Study area Health and Behavioural Sciences, Medicine, Science and Mathematics
HDR funding type Living stipend scholarship, Top-up Scholarship, Tuition Scholarship
Scholarship value $28,092 per annum (2020 rate), tax free, indexed annually, and a top-up of $5,000 per annum from the second year.
Scholarship duration Three years with the possibility of two 6-month extensions in approved circumstances.
Opening date 6 August 2019
Closing date 22 September 2019

Scholarship description

The brain is considered to be the last frontier, both in terms of understanding how it operates and in accessing it for therapeutic intervention. Our laboratory works in both spaces: deciphering the role of key molecules and signalling pathways in Alzheimer's disease (AD) and developing novel ultrasound-based techniques to overcome the blood-brain barrier (BBB). The BBB restricts the flow of blood-borne substances into the interstitial brain space, facilitated by tight junctions between the cells that constitute the blood vessels thereby hindering paracellular transport, and a very low number of vesicles, thereby reducing transcytosis. Application of pulsed ultrasound (US) in the presence of intravenously injected microbubbles has been shown to transiently open the BBB in different model organisms. In previous studies by our laboratory, we demonstrated that delivery of ultrasound to Alzheimer's mice was sufficient to remove amyloid plaques and tau tangles and restore cognitive function. The study will use imaging technology such as two-photon microscopy to investigate the dynamics of BBB opening following ultrasound treatment aided by the used of fluorescently labelled dextrans, thereby contributing to our strategies of using ultrasound as a therapy for Alzheimer's disease.

Eligibility

To be eligible to apply you must meet the entry requirements for Higher Degrees by Research at UQ, please visit the Graduate School's website.

Applications are closed.

Before you apply

If this scholarship has rules, download and read them before applying.

How to apply

To apply for admission and scholarship, follow the link on the upper right hand side of this page. There is no separate application for scholarship because you will be given the opportunity to request scholarship consideration on the application for admission.

Prior to applying, check your eligibility and prepare your documentation.

You should also contact Professor Jürgen Götz (j.goetz@uq.edu.au) to discuss your suitability for this scholarship prior to submitting an application.

Please ensure that you

  1. select 'I am applying for, or have been awarded a scholarship or sponsorship'
  2. enter in the free-text field ‘BBB’
  3. list the enrolling unit as the Queensland Brain Institute
  4. enter Professor Jürgen Götz as your supervisor

Selection criteria

Applicants will have a Bachelor of Science with Honours or Masters equivalent.

Applications are closed.

Contact

Professor Jürgen Götz
+61 7 3346 6329
Applications are closed.

Terms and conditions

Read the policy on UQ Research Scholarships.

A domestic part-time student with carer’s responsibilities, a medical condition or a disability, which prevents them from studying full time may be eligible for scholarship consideration, on a case by case basis.

Applications are closed.